Lale Ozcan Lab

Columbia University Department of Medicine


Our focus is to identify novel pathways involved in the regulation of glucose and cholesterol metabolism in the setting of obesity. Using biochemical, molecular and cellular biology techniques and animal models of human disease, we aim to bring new insights into complex metabolic abnormalities and identify potential therapeutic targets.

Selected Publications

  • Wang Y, Tinsley B, Spolitu S, Zadroga J, Agarwal H, Sarecha AK, Ozcan L. Geranylgeranyl isoprenoids and hepatic Rap1a regulate basal and statin-induced expression of PCSK9. Journal of Lipid Research 1:100515
  • Agarwal H, Tinsley B, Sarecha AK, Ozcan L. Rap1 in the context of PCSK9, atherosclerosis, and diabetes. Current Atherosclerosis Reports 25(12):931-937
  • Wang Y, Spolitu S, Zadroga JA, Sarecha AK, Ozcan L. Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia. Cell Reports 40(8):111259
  • Dai W, Choubey M, Patel S, Singer HA, Ozcan L. Adipocyte CaMKII deficiency improves obesity-associated glucose intolerance. Molecular Metabolism 53:100130
  • Spolitu S, Okamoto H, Dai W, Zadroga JA, Wittchen ES, Gromada J, Ozcan L. Hepatic glucagon signaling regulates PCSK9 and LDL-cholesterol. Circulation Res., 124:38-51 #Recommended on Faculty of 1000 (F1000) Prime.
  • Spolitu S, Dai W, Zadroga JA, Ozcan L. PCSK9 and Lipid Metabolism. Curr Opin Lipidol. 30(3):186-191
  • Ghorpade D, Ozcan L, Zheng Z, Nicoloro SM, Shen Y, Chen E, Blüher M, Czech MP, Tabas I. Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature 555(7698):673-677
  • Ozcan L, Ghorpade DS, Zheng Z, de Souza JC, Chen K, Bessler M, Bagloo M, Schrope B, Pestell R, Tabas I. Hepatocyte DACH1 is increased in obesity via nuclear exclusion of HDAC4 and promotes hepatic insulin resistance. Cell Reports, (10):2214-2225
  • Ozcan L, Xu X, Deng SX, Ghorpade DS, Thomas T, Cremers S, Hubbard B, Serrano-Wu MH, Gaestel M, Landry DW, Tabas I. Treatment of obese insulin resistant mice with an allosteric MAPKAPK2/3 inhibitor lowers blood glucose and improves insulin senstivity. Diabetes, 141945
  • Ozcan L, de Souza JC, Harari A, Backs J, Olson EN, Tabas I. Activation of calcium/calmodulin- dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling. Cell Metab., 18, 1-12
  • Ozcan L, Wong CCL, Li G, Xu T, Park SKR, Wronska A, Chen BX, Marks AR, Fukamizu A, Backs J, Singer HA, Yates JR III, Accili D, Tabas I. Regulation of hepatic glucose production by a calcium-sensing enzyme, CaMKII. Cell Metab., 15, 1-13

Lale Ozcan, M.D.

Principal Investigator

Postdoctoral fellowships, Columbia and Harvard Universities
M.D. 2004, Istanbul University, Cerrahpasa School of Medicine

Heena Agarwal, PhD

Postdoctoral Research Scientist

Ameesh Sarecha

Undergraduate Student

Brea Tinsley

Graduate Student

Lab Alumni

Elizabeth Abraham

Undergraduate Student

Noor M. Bittar

Institute of Human Nutrition, Master’s Student

Current status: Medical Student, Indiana University School of Medicine, IN, USA

Mayank Choubey, PhD

Postdoctoral Research Scientist

Current status: Associate Research Scientist, NYU Langone Health Long Island School of Medicine, NY, USA

Wen Dai, MD, PhD

Postdoctoral Research Fellow

Current status: Postdoctoral Research Fellow at the Medical College of Wisconsin, WI, USA

Nathaniel Kleytman

Institute of Human Nutrition, Master’s Student

Current status: Medical Student, St. George’s University School of Medicine, Grenada, West Indies

Sonal Patel, PhD

Postdoctoral Research Scientist

Current status: Research Scientist II at Fusion Pharmaceuticals Inc, ON, Canada

Aishwarya Rao

Undergraduate Student

Stefano Spolitu, PhD

Postdoctoral Research Fellow

Current status: Senior Medical Copywriter at BB&C Group, Milan, Italy

Sarah A. Tydings

Institute of Human Nutrition, Master’s Student

Current status: Medical Student, University of Rochester School of Medicine, NY, USA

Pavithra Veera

Undergraduate Student

Yating Wang, MD, PhD

Postdoctoral Research Scientist

Current status: Cardiology Resident at The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China

John A. Zadroga, DO

Undergraduate Student

Current status: Medical Genetics Fellow, Mayo Clinic, Rochester, MN, USA


Lale Ozcan, M.D.
Assistant Professor
Department of Medicine
Columbia University


650 West 168th Street
New York, NY, 10032
Room BB 905